News Scan for Mar 19, 2014
Emerging tick-borne bacterium
; NYC measles outbreak
; Haemophilus influenzae in pregnancy
; ;
Emerging tick-borne bacterium threatens immunocompromised patients
An emerging tick-borne bacterium in Europe, Asia, and Africa poses a risk for immunocompromised patients, causing an illness that could be mistaken for an underlying disease, according to a study published yesterday in Clinical Infectious Diseases.
The bacterium, widespread in ticks, rats, mice, and voles, was discovered in Japan in 2004 and was first recognized as a human pathogen in 2010, says the report by a European team. It is calledCandidatus Neoehrlichia mikurensis, with the first term signifying that no one has reported cultivating it as yet.
The authors gathered data on 11 European patients with hematologic malignances or autoimmune diseases in whom the infection was diagnosed from 2010 to 2013.
The patients were mostly older men (median age, 67); all but one had ongoing or recent immunosuppressive treatment, and 8 of 11 had undergone splenectomy, the report says. Less than half of them recalled tick exposure.
The most frequent symptoms were fever (in 11 of 11), pain in muscles and/or joints (8 of 11), vascular and thromboembolic events such as deep vein thrombosis (6 of 11), transitory ischemic attacks (2), pulmonary embolism (1), and arterial aneurysm (1).
The median time from first symptoms to correct diagnosis was 2 months. In at least four cases, the condition was attributed to the underlying disease, and immunosuppressive therapy was scheduled. All the patients recovered with doxycycline treatment.
The authors conclude that Ca Neoehrlichia mikurensis is "an emerging tick-borne pathogen that may give rise to a systemic inflammatory syndrome in persons with hematologic or autoimmune diseases that could be mistaken for recurrence of the underlying disease and/or unrelated arteriosclerotic vascular events. Awareness of this new pathogen is warranted among rheumatologists, hematologists, oncologists, and infectious disease specialists."
Mar 18 Clin Infect Dis abstract
Mar 18 Clin Infect Dis abstract
NYC officials probing healthcare link in measles outbreak
A 20-case outbreak of measles that is concentrated in northern Manhattan might have been spread in medical facilities after healthcare workers failed to recognize the disease quickly enough and isolate infected patients, a New York City epidemiologist told the New York Times.
Jay K. Varma, MD, deputy commissioner for disease control in the New York City Department of Health and Mental Hygiene, said the department is investigating whether any of the cases resulted from exposure in healthcare facilities. The first outbreak case was detected in early February.
"We know a number of people were exposed and possibly got their infection either at a doctor’s office or at an emergency room where they went and it took more time than it should have for them to be put in an isolation area where they couldn’t possibly infect anyone else," Varma said.
Mar 18 New York Times article
Mar 18 New York Times article
In related news, California health officials said that 19 of 32 confirmed measles cases so far this year have been in patients who were not vaccinated, 14 of whom were intentionally not vaccinated, according to Southern California Public Radio (SCPR).
California allows parents to opt out of childhood vaccines if they fill out a personal belief exemption form and discuss the issue with a doctor, but state health authorities are urging parents not to go that route, fearing disease resurgence. At this time last year the state had confirmed only three measles cases.
Mar 18 SCPR story
Mar 18 SCPR story
UK study shows higher risk of H influenzae in pregnancy
Pregnancy was associated with a greater incidence of Haemophilus influenzae infections in UK women of reproductive age, and the disease was consequently linked to very high rates of premature births and stillbirths, according to a surveillance study today in the Journal of the American Medical Association (JAMA).
Researchers from Public Health England asked general practitioners who cared for girls or women 15 to 44 years old who had a lab-confirmed H influenzae infection from 2009 through 2012 to complete a questionnaire about 3 months after infection. With 171 infections reported, the overall risk was low: 0.50 per 100,000 women. Seventy-five of those patients were pregnant.
The vast majority of those cases—144, or 84%—involved unencapsulated strains, compared with 11 (6.4%) from serotype b and 16 (9.4%) from other encapsulated strains. The investigators found that the incidence of unencapsulated H influenzae disease was 17.2 times greater in pregnant women.
They also found that infection with unencapsulated strains during the first 24 weeks of pregnancy was associated with fetal loss in 44 of 47 women and extremely premature birth in the other 3. In the second half of pregnancy the infection was associated with 8 cases of premature birth and 2 cases of stillbirth among 28 women. Pregnancy loss following H influenzae disease was 2.9 times higher than the UK average.
The authors conclude, "The increased incidence of invasive H influenzae disease among pregnant women was reminiscent of Listeria monocytogenes infections but with a much higher rate of fetal loss."
Mar 19 JAMA study
Mar 19 JAMA editorial on the study
Mar 19 JAMA news release
Mar 19 JAMA study
Mar 19 JAMA editorial on the study
Mar 19 JAMA news release
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- 20 Mar 2014 MERS-CoV - Eastern Mediterranean (17): Kuwait, UAE, Saudi Arabia, WHO, RFI
- 20 Mar 2014 Late blight, potato - Bangladesh: (KH)
- 20 Mar 2014 Yellow fever - Americas (03): Peru, RFI
- 20 Mar 2014 Candidatus Neoehrlichia mikurensis - Europe: tick-borne path, immunocompromised
- 20 Mar 2014 Rabies - Philippines (03): (AK) corr
- 20 Mar 2014 Streptococcus, group A, scarlet fever - UK (06): (England) RFI
- 20 Mar 2014 Ricin, powder - USA: (Washington DC)
- 20 Mar 2014 Hendra virus, equine - Australia: (QL)
- 20 Mar 2014 Porcine reprod. & resp. syndrome - USA: (SD)
- 19 Mar 2014 Porcine epidemic diarrhea - Colombia: (HU, CU)
- 19 Mar 2014 Undiagnosed viral hemorrhagic fever - Guinea: (NZ) RFI
- 19 Mar 2014 Poliomyelitis - update (05): Iraq, RFI
- 19 Mar 2014 Porcine epidemic diarrhea - Japan: (FO) susp.
- 19 Mar 2014 Anthrax, livestock - Lesotho: OIE
- 19 Mar 2014 Brucellosis, cervid - USA: (MT)
- 19 Mar 2014 Anthrax - Pakistan: (KP) nilgai
- 19 Mar 2014 Undiagnosed illness - Lebanon: (NL) respiratory, fatal, RFI
- 19 Mar 2014 Foot & mouth disease - N Korea (04): FAO, RFI
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- 19 Mar 2014 Lyme disease - USA (02): (WI) increased incidence
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- 18 Mar 2014 Rift Valley fever - Senegal: (DK) bovine, OIE, 2013
- 18 Mar 2014 Anthrax, human, livestock, 2013 - Argentina
- 18 Mar 2014 Novel henipa-like virus - China: (YN) 2012, rat
- 18 Mar 2014 Gnathostomiasis - USA: risk from imported eels
- 18 Mar 2014 Malaria - Angola: (CB)
- 18 Mar 2014 Meningitis, meningococcal - Ghana: (NP) susp, fatal, RFI
- 17 Mar 2014 Avian influenza, human (86): China, H7N9, WHO
- 17 Mar 2014 MERS-CoV - Eastern Mediterranean (15): Saudi Arabia, WHO, RFI
- 17 Mar 2014 Dengue & chikungunya co-infection - Portugal ex Angola
- 17 Mar 2014 Dengue/DHF update (23): Asia, Pacific, Middle East
- 17 Mar 2014 Dengue/DHF update (22): Americas
- 17 Mar 2014 Rabies, animal - Uzbekistan: (JI) canine, livestock, RFI
- 17 Mar 2014 Avian influenza (42): Netherlands (GE) poultry, LPAI H5N2, OIE
- 17 Mar 2014 Poliomyelitis - update (04): Cameroon, Ethiopia, global
- 17 Mar 2014 Avian influenza, human (85): Cambodia (KP, KN, KG), H5N1
- 17 Mar 2014 Meningitis, meningococcal - USA (02): (PA) fatal, college, sg. B
- 17 Mar 2014 Rabies - Taiwan: ferret-badger, update, OIE
- 17 Mar 2014 Venezuelan hemorrhagic fever - Venezuela: susp, RFI
- 17 Mar 2014 Leishmaniasis - Pakistan: (KP)
- 17 Mar 2014 Infectious bursal disease, poultry - USA: (WA)
- 17 Mar 2014 Measles update (11)
- 16 Mar 2014 Hepatitis E- Uganda (02): (Karamoja)
- 16 Mar 2014 Chikungunya (21): Caribbean
- 16 Mar 2014 Avian influenza (41): South Korea, HPAI H5N8, poultry, canine susp, genotyping
- 16 Mar 2014 Rabies - Philippines (03): (AK) human, canine, vaccination
- 16 Mar 2014 Porcine epidemic diarrhea - North America (10): USA (AZ)
- 16 Mar 2014 Zika virus - Pacific (08)
- 16 Mar 2014 Leptospirosis, canine - USA: (FL)
- 16 Mar 2014 Hantavirus update - Americas (09): Peru
- 15 Mar 2014 Rabies - Philippines (02): (SC), canine, human, vaccination program
- 15 Mar 2014 Rabies - Greece: (TC) canine
- 15 Mar 2014 Bovine respiratory disease - Australia: boat voyage
- 15 Mar 2014 Bovine illness/death - USA: poss. drug related
- 14 Mar 2014 White nose syndrome, bats - North America (06): (GA)
- 14 Mar 2014 Avian influenza, human (84): China, H7N9, WHO
- 14 Mar 2014 HIV - USA: (TX) transmission, WSW, 2012
- 14 Mar 2014 MERS-CoV - Eastern Mediterranean (14): Saudi Arabia, RFI
- 14 Mar 2014 Salmonellosis - USA (03): multiple serotypes, live poultry contact, 2013
- 14 Mar 2014 Dietary supplement, hepatic toxicity - USA
- 14 Mar 2014 Hepatitis B & C, HIV - USA: (NY) possible insulin syringe exposure
- 14 Mar 2014 Meningitis, meningococcal - Ethiopia: susp, RFI
- 14 Mar 2014 Corn cyst nematode, maize - Afghanistan: 1st rep (NG)
- 14 Mar 2014 Infectious salmon anemia - Norway (03): (TR) conf, OIE
- 13 Mar 2014 MERS-CoV - Eastern Mediterranean (13): Saudi Arabia, UAE, WHO
- 13 Mar 2014 Rabies - Canada (02): (ON) bat, control, 2013
- 13 Mar 2014 Conjunctivitis - Oman: (Muscat) expatriates
- 13 Mar 2014 Plum pox virus - Israel: 1st rep (HA)
- 13 Mar 2014 Meat contamination - USA: (FL) RFI
- 13 Mar 2014 African horse sickness - South Africa (02): (WC) serotype pending, OIE
- 13 Mar 2014 Avian influenza (40): Germany (NI) poultry, LPAI H5N1, OIE
- 13 Mar 2014 Septoria, wheat - Australia: new strains, alert
- 13 Mar 2014 Avian influenza (39): Libya (Tubruq) HPAI H5N1, poultry, OIE
- 12 Mar 2014 BSE, bovine - Greece: (TC) susp, RFI
- 12 Mar 2014 Pertussis - Spain: (VC)
- 12 Mar 2014 Panama disease, banana - Peru: (LL)
- 12 Mar 2014 Poliomyelitis - update (03): Lebanon ex Syria, susp, global, RFI
- 12 Mar 2014 Undiagnosed illness - Kenya: (BA) human fatal, livestock, RFI
- 12 Mar 2014 Ciguatera fish poisoning - Australia: (NS)
- 12 Mar 2014 Hepatitis C - India (03): (Northeast states) IV drug users
- 12 Mar 2014 Syphilis - USA (04): (NY) increased incidence, MSM, mobile phone apps
- 12 Mar 2014 Streptococcus, group A, scarlet fever - UK (05): (England) RFI
- 11 Mar 2014 Avian influenza (38): Viet Nam, H5N1, mutation, spread, poultry, vaccine
- 11 Mar 2014 Undiagnosed outbreak - Nigeria: (BO) fatal
- 11 Mar 2014 Anthrax - Argentina (03): (BA) bovine
- 10 Mar 2014 Dengue/DHF update (21): Asia, Pacific, Middle East
- 10 Mar 2014 Dengue/DHF update (20): Americas
- 10 Mar 2014 Avian influenza, human (83): Cambodia (KG, KN) H5N1, RFI
- 10 Mar 2014 Platydemus manokwari - France: invasive
- 10 Mar 2014 Announcements (03): ProMED-mail seeking viral disease moderator
- 10 Mar 2014 Chikungunya (21): Caribbean
- 10 Mar 2014 Moko disease, banana - Malaysia: 1st rep
- 09 Mar 2014 Avian influenza (37): China, LPAI H7N9, poultry, epidemiology, vaccine, RFI
- 09 Mar 2014 Yellow fever - Africa (03): Nigeria, cards
- 09 Mar 2014 Zika virus - Pacific (07): Easter Island, French Polynesia
- 09 Mar 2014 Measles update (10)
- 09 Mar 2014 NDM carrying Gram-negative bacilli - Americas: Update
- 08 Mar 2014 Rabies vaccine, serious adverse events - India: (PB) fatality, RFI
- 08 Mar 2014 Enterobacteriaceae, carbapenem resistant - UK: (England) increased incidence
- 08 Mar 2014 Prion disease update 2014 (03): comment
- 08 Mar 2014 Foot & mouth disease - Guinea: (MD) bovine, OIE
- 08 Mar 2014 Porcine reprod. & resp. syndrome - Switzerland: (LU) OIE
- 08 Mar 2014 Mumps - USA: (OH) university students
- 08 Mar 2014 Avian influenza, human (82): Cambodia, H5N1
- 08 Mar 2014 Avian influenza, human (81): China, H7N9, WHO
- 07 Mar 2014 Rabies - Israel (02): (HZ) wolf, human
- 07 Mar 2014 Rabies - Zimbabwe: (MA) human, canine
- 07 Mar 2014 Porcine epidemic diarrhea - North America (09): Canada, feed products, RFI
- 06 Mar 2014 Undiagnosed disease, black pepper - India: (KA)
- 06 Mar 2014 Avian influenza (36): China, LPAI H7N9, poultry, monitoring, RFI
- 06 Mar 2014 Prion disease update 2014 (02): vCJD blood test verified
- 06 Mar 2014 Brucellosis - Cyprus: (Northern Cyprus) susp, RFI
- 06 Mar 2014 Avian influenza, human (80): China, H7N9, WHO
- 06 Mar 2014 MERS-CoV - Eastern Mediterranean (12): Saudi Arabia
- 06 Mar 2014 Streptococcus, group A, scarlet fever - UK (04): (Scotland) RFI
- 06 Mar 2014 Pertussis - USA (02)
- 06 Mar 2014 Rabies - Nigeria (03): dog butchering, comments
- 06 Mar 2014 Acute encephalitis syndrome - India: (UP) R. prowazekii/head lice susp, RFI
- 06 Mar 2014 Hepatitis C - USA (02): (MN)
- 06 Mar 2014 Hantavirus update - Americas (08): Panama (LS)
- 06 Mar 2014 Mycobacterium marinum - USA: (New York City) Chinatown, raw fish exposure
- 06 Mar 2014 Rabies - Canada: (SK) bat
- 06 Mar 2014 Infectious salmon anemia - Norway (02): (TR) susp, RFI
- 06 Mar 2014 Brown streak and mosaic, cassava - Tanzania: (MA, MZ)
- 05 Mar 2014 Rabies - Nigeria (02): dog butchering, comment
- 05 Mar 2014 Anthrax - Kenya (02): (KK) human, bovine
- 05 Mar 2014 Cholera, diarrhea & dysentery update (08): Africa
- 05 Mar 2014 Salmonellosis, st Heidelberg - USA (03): chicken, continued alert
- 05 Mar 2014 African swine fever - Russia (05): (VG) wild boar, OIE, RFI
- 04 Mar 2014 Kyasanur forest disease - India (02): (KL)
- 04 Mar 2014 Little cherry disease - Australia (02): LChV-2, 1st rep (TS)
- 04 Mar 2014 Infectious salmon anemia - Norway: (NO) OIE
- 04 Mar 2014 Streptococcus, group A, scarlet fever - UK (03): (England) RFI
- 03 Mar 2014 Avian influenza, human (79): China, H7N9, WHO
- 03 Mar 2014 Staph. aureus (MRSA), comm. assoc. - China: (HK)
- 03 Mar 2014 Malaria, P. knowlesi, human - Malaysia
- 03 Mar 2014 Rabies - Philippines: Mindanao
- 03 Mar 2014 Salmonellosis - Australia: (VI) eggs
- 03 Mar 2014 Dengue/DHF update (19): Asia, Pacific
- 03 Mar 2014 Dengue/DHF update (18): Americas
- 03 Mar 2014 Avian influenza (35): Netherlands (FL) poultry, LPAI, H5N1, OIE
- 03 Mar 2014 African horse sickness - South Africa: (NL, GT)
- 03 Mar 2014 Zika virus - Pacific (06): French Polynesia, New Caledonia
- 02 Mar 2014 Rabies update - USA (01): (NV) canine
- 02 Mar 2014 Chikungunya (20): Caribbean
- 02 Mar 2014 Anthrax - Kyrgyzstan: bovine 2013
- 02 Mar 2014 Streptococcus, group A, scarlet fever - UK (02): England
- 02 Mar 2014 Measles update (09)
- 02 Mar 2014 Avian influenza (33): China (HN) LPAI H7N9, poultry, OIE
- 02 Mar 2014 Avian influenza (34): South Korea, HPAI H5N8, poultry, spread, OIE
- 01 Mar 2014 Severe fever w/ thrombocytopenia synd. - Japan: (western)
- 01 Mar 2014 Syphilis & gonococcal disease - USA (03): (ND) increased incidence,
- 01 Mar 2014 MERS-CoV - Eastern Mediterranean (11): Saudi Arabia, WHO
- 01 Mar 2014 Rabies - Nigeria, dog butchering
- 01 Mar 2014 Pertussis - USA
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