Nonrandomized intervention study of naloxone coprescription for primary care patients receiving long-term opioid therapy for pain.

Coffin PO, Behar E, Rowe C, Santos GM, Coffa D, Bald M, Vittinghoff E. Ann Intern Med. 2016 Jun 27; [Epub ahead of print].

Opioid medications carry significant risk of adverse drug events. This observational study found that patients prescribed naloxone to treat overdose in home and community settings were less likely to have opioid-related emergency department visits compared to those not prescribed naloxone. This finding demonstrates the safety benefit of prescribing naloxone in outpatients.

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