lunes, 5 de marzo de 2018

Prevalence of latent tuberculosis infection among foreign students in Lübeck, Germany tested with QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold Plus | Journal of Occupational Medicine and Toxicology | Full Text

Prevalence of latent tuberculosis infection among foreign students in Lübeck, Germany tested with QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold Plus | Journal of Occupational Medicine and Toxicology | Full Text

Journal of Occupational Medicine and Toxicology

Prevalence of latent tuberculosis infection among foreign students in Lübeck, Germany tested with QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold Plus

  • Elia Noemi Gallegos MoralesEmail author,
  • Johannes Knierer,
  • Anja Schablon,
  • Albert Nienhaus and
  • Jan Felix Kersten
Journal of Occupational Medicine and Toxicology201712:12
Received: 30 March 2017
Accepted: 12 May 2017
Published: 25 May 2017

Abstract

Background

The tuberculosis (TB) incidence rate in foreign-born individuals has been increasing in Germany in recent years. Foreign students may be an important source of latent tuberculosis infection (LTBI) in low-incidence countries. In Germany, there are no guidelines for LTBI screening of foreign students. The aim of the study was to estimate LTBI prevalence and evaluate associated risk factors among foreign students in Germany. The second purpose of our study was to compare the results of the new generation of QuantiFERON-TB Gold Plus (QFT-Plus) to those of its predecessor QuantiFERON-TB Gold In-Tube (QFT-GIT).

Methods

This cross-sectional study was conducted between February 2016 and March 2016. Foreign students and young professionals attending the university and higher education institutes in Lübeck, Germany were tested with QFT-Plus and QFT-GIT. Participants filled out a questionnaire for the purpose of LTBI risk assessment and analysis. Variables associated with a positive test result were analyzed using logistic regression.

Results

One hundred thirty four students participated in the study. The overall prevalence as regards positive results from both tests, QFT-Plus and QFT-GIT, was 9.7%, and the prevalence of positive QFT-Plus results was 8.2%. The main independent variables associated with a positive QFT-Plus result were a) being born in a high-incidence country (OR = 6.7, 95% CI: 1.3–34.3) and b) previous contact with a person with active TB (OR = 4.5, 95% CI: 1.1–18.3). Higher age (OR = 2.8, 95% CI: 0.7–11.3) and male gender (OR = 1.6, 95% CI: 0.4–6.7) showed a tendency toward positive QFT-Plus results but this was not statistically significant. Agreement between QFT-Plus and QFT-GIT results was κ = 0.85, p < 0.001.

Conclusions

The LTBI prevalence among foreign students was about 10%. We recommend implementing a policy whereby all foreign students are screened by means of a questionnaire about LTBI risk factors, so that only students with present risk factors are tested for LTBI. The agreement between the new QFT-Plus and the QFT-GIT (κ = 0.85) was good. QFT-Plus might be used in the same format as its predecessor.

Keywords

Foreign studentsLatent tuberculosis infectionRisk factorsQuantiFERON-TB Gold Plus

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